The three-time world champion will face Martin Gould in Sunday's final, after the world number 53 stunned world number one Judd Trump 6-3 in the other semifinal.
Four minutes later it was 2-0 after Mane slotted the ball home after a terrible error from Chelsea keeper Kepa Arrizabalaga, whose attempted clearance was blocked by the forward.
The 23-year-old broke the deadlock in the 74th minute by thumping in a long-range effort after combining with Darlan Mendes.
The 2020 COSAFA is tentatively scheduled for Oct. 2 to 17 in Durban, South Africa, while the AFCON qualifiers will resume in November.
Ibrahimovic was close to finding the net in the 11th minute as his attempt went just inches past the far post after a meandering run in the box.
In the Changzhou division, Kunshan FC edged Changchun Yatai 1-0, Nantong Zhiyun held a 1-1 draw with Sichuan Jiuniu, and Xinjiang Tianshan Leopard tied with Heilongjiang Lava Spring 0-0. Enditem
The match will be played at the Azteca stadium in Mexico City on September 30, starting at 9pm local time, according to an FMF statement.
Rafael Veiga had put the visitors ahead by latching on to a Matias Vina cross with a low finish in the 71st minute.
The London club said their medical team was informed of the test results as the team was at London Stadium preparing for their Tuesday evening's EFL Cup third-round match against Hull City.
"We are now more than halfway through our journey but face an uphill battle ahead," the vice president and secretary-general of the Beijing 2022 Organizing Committee told Xinhua in an exclusive interview.
Brighton produced a surprise as they won 3-0 away to Newcastle United. Neil Maupay scored twice in the opening seven minutes, the first from the penalty spot, and Aaron Connelly added a third with seven minutes left to play.